Mucosal vaccine adjuvants update
نویسندگان
چکیده
منابع مشابه
Mucosal vaccine adjuvants update
Mucosal vaccination, capable of inducing protective immune responses both in the mucosal and systemic immune compartments, has many advantages and is regarded as a blue ocean in the vaccine industry. Mucosal vaccines can offer lower costs, better accessability, needle-free delivery, and higher capacity of mass immunizations during pandemics. However, only very limited number of mucosal vaccines...
متن کاملModes of Action for Mucosal Vaccine Adjuvants
Vaccine adjuvants induce innate immune responses and the addition of adjuvants to the vaccine helps to induce protective immunity in the host. Vaccines utilizing live attenuated or killed whole pathogens usually contain endogenous adjuvants, such as bacterial cell wall products and their genomic nucleic acids, which act as pathogen-associated molecular patterns and are sufficient to induce adap...
متن کاملNovel Vaccine Adjuvants
Vaccines still remain the most successful method for protection and eradication against diseases. However, to avoid harmful effects associated with whole organism vaccines, new vaccine candidates are composed of parts of an organism, and therefore these are weakly immunogenic. Adjuvants are essential components of vaccines that nonspecifically stimulate the immune system, particularly the innat...
متن کاملCpG oligodeoxynucleotides as mucosal adjuvants
Bacterial DNA comprising palindromic sequences and containing unmethylated CpG is recognized by toll-like receptor 9 of plasmacytoid dendritic cells (pDCs) and induces the production of interferon-α and chemokines, leading to the activation of a Th1 immune response. Therefore, synthetic equivalents of bacterial DNA (CpG oligodeoxynucleotides) have been developed for clinical applications. They ...
متن کاملVaccine Adjuvants Revisited
A huge amount of evidence has been made available on various adjuvants as immunological auxiliaries. Very few of them, however, have made it into commercial vaccines. Their defining properties and uses are discussed in the following mini-review. WHAT IS AN ADJUVANT? In Freund's words [1] an adjuvant should “evoke very abundant serum antibody production sustained for an unexpectedly long time”. ...
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ژورنال
عنوان ژورنال: Clinical and Experimental Vaccine Research
سال: 2012
ISSN: 2287-3651,2287-366X
DOI: 10.7774/cevr.2012.1.1.50